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According to the most common definition a DNA-bank is a system of a genetic material storage. Applying to nuclear-chemical plant workers, DNA-bank creation is determined by the necessity to preserve a hereditary material of these people and their descendants for the further evaluation of consequences of technogenic factors action on human genome using a contemporary conceptual and applied advances of genetics. In the frameworks of the study of technogenic factors influence on human genome and genetic-caused disorders development the Seversk Biophysical Research Center is being created DNA-bank of Siberian Group of Chemical Enterprises workers exposed to radiation, their descendants, and ZATO Seversk and Tomsk city inhabitants. The DNA-bank will be a basis for all major research laboratory projects: analysis of molecular basis of individual radiosensitivity; analysis of technogenic factors role in congenital malformations and hereditary diseases development in nuclear-chemical plant workers offspring; elaboration of genotype-specific test-systems of cancer prognosis and development of cardiovascular and other common disorders connected with the effect of technogenic factors. The DNA-bank creation is a technological issue aggravated by ethical problems. Whereas the DNA isolation is not a problem today, ethical complication is debated widely in the world. These questions strongly arise in a view of advances of Human Genome Project. Information consent on DNA usage is imperative today. Also questions on DNA property (who is its owner, a donor or a "banker"?) and of a confidentiality, which maintenance is a doubtable question in a case of multiple genetic testing, are not solved today. At present, the Genomic Medicine Laboratory disposes the DNA samples of more than 400 Seversk and Tomsk inhabitants affected with breast and lung cancer. More than 800 blood samples of main manufacture of the Siberian Group of Chemical Enterprises workers are collected. About 1500 DNA samples are planned to be collected by the end of 2004. All participants gave an information consent. A computer program to support the DNA-bank and for integration of the genetic information obtained on its basis by medico-dosimetric register created by the Seversk Biophysical Research Center is under construction.